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Infect. Immun., Sep 1997, 3970-3975, Vol 65, No. 9
Copyright © 1997, American Society for Microbiology

A putative leucine zipper activator of Pasteurella haemolytica leukotoxin transcription and the potential for modulation of its synthesis by slipped-strand mispairing

SK Highlander and VT Hang
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA. sarahh@bcm.tmc.edu

A Pasteurella haemolytica cosmid clone that activates leukotoxin transcription in Escherichia coli has been isolated. The activator locus, alxA, is part of a continuous open reading frame that includes the type I hsdM methylase gene. AlxA and HsdM peptides are processed from a precursor, and translation of the polyprotein can be modulated by slipped-strand mispairing across a pentanucleotide repeat, ACAGC, within the 5' end of alxA-hsdM. Extracts containing AlxA can bind to a leukotoxin promoter fragment.

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