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Infect. Immun., 01 1998, 361-363, Vol 66, No. 1
Copyright © 1998, American Society for Microbiology

Extensive immunoglobulin binding of Plasmodium falciparum-infected erythrocytes in a group of children with moderate anemia

C Scholander, J Carlson, PG Kremsner and M Wahlgren
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.

Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum-infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.

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