This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Choi, J.-I.
Right arrow Articles by Kim, B.-W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Choi, J.-I.
Right arrow Articles by Kim, B.-W.

 Previous Article  |  Next Article 

Infect. Immun., Jan 1998, 391-393, Vol 66, No. 1
Copyright © 1998, American Society for Microbiology

Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes

JI Choi, RE Schifferle, F Yoshimura and BW Kim
Department of Pediatrics, University of Rochester, New York 14642, USA. vaccine@cc.urmc.rochester.edu

The effect of immunization with either a Porphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu- PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate from P. gingivalis could potentially be developed as a vaccine against periodontal infection by P. gingivalis.


This article has been cited by other articles:

  • d'Empaire, G., Baer, M. T., Gibson, F. C. III (2006). The K1 Serotype Capsular Polysaccharide of Porphyromonas gingivalis Elicits Chemokine Production from Murine Macrophages That Facilitates Cell Migration. Infect. Immun. 74: 6236-6243 [Abstract] [Full Text]  
  • Gonzalez, D., Tzianabos, A. O., Genco, C. A., Gibson III, F. C. (2003). Immunization with Porphyromonas gingivalis Capsular Polysaccharide Prevents P. gingivalis-Elicited Oral Bone Loss in a Murine Model. Infect. Immun. 71: 2283-2287 [Abstract] [Full Text]  
  • Gravekamp, C., Kasper, D. L., Paoletti, L. C., Madoff, L. C. (1999). Alpha C Protein as a Carrier for Type III Capsular Polysaccharide and as a Protective Protein in Group B Streptococcal Vaccines. Infect. Immun. 67: 2491-2496 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»