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Infection and Immunity, October 1998, p. 5027-5030, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Organ-Dependent Variation of Capsule Thickness in
Cryptococcus neoformans during Experimental Murine Infection
Johanna
Rivera,1
Marta
Feldmesser,2
Michael
Cammer,3 and
Arturo
Casadevall1,2,*
Department of Microbiology and
Immunology,1
Department of Medicine
(Division of Infectious Diseases),2 and
Department of Anatomy and Structural
Biology,3 Albert Einstein College of Medicine,
Bronx, New York 10461
Received 11 May 1998/Returned for modification 23 June
1998/Accepted 22 July 1998
In studies of murine infection, the capsule thickness of
Cryptococcus neoformans varied depending on the
organ. The relative order of thickness was as follows:
lung > brain > in vitro isolates. The differences in
capsule thickness suggest that there are organ-related differences in the expression of genes responsible for capsule thickness.
*
Corresponding author. Mailing address: Albert Einstein
College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-4259. Fax: (718) 430-8701. E-mail:
casadeva{at}aecom.yu.edu.
Infection and Immunity, October 1998, p. 5027-5030, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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