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Infection and Immunity, October 1998, p. 5027-5030, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Organ-Dependent Variation of Capsule Thickness in Cryptococcus neoformans during Experimental Murine Infection

Johanna Rivera,1 Marta Feldmesser,2 Michael Cammer,3 and Arturo Casadevall1,2,*

Department of Microbiology and Immunology,1 Department of Medicine (Division of Infectious Diseases),2 and Department of Anatomy and Structural Biology,3 Albert Einstein College of Medicine, Bronx, New York 10461

Received 11 May 1998/Returned for modification 23 June 1998/Accepted 22 July 1998

In studies of murine infection, the capsule thickness of Cryptococcus neoformans varied depending on the organ. The relative order of thickness was as follows: lung > brain > in vitro isolates. The differences in capsule thickness suggest that there are organ-related differences in the expression of genes responsible for capsule thickness.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-4259. Fax: (718) 430-8701. E-mail: casadeva{at}aecom.yu.edu.

Infection and Immunity, October 1998, p. 5027-5030, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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