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Infection and Immunity, October 1998, p. 5031-5035, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hlyA) Mutant in Gnotobiotic Pigletsdagger

Rodney A. Moxley,1,* Emil M. Berberov,1 David H. Francis,2 Jun Xing,1,Dagger Mahtab Moayeri,3 Rodney A. Welch,3 Diane R. Baker,2 and Raúl G. Barletta1

Departments of Veterinary and Biomedical Sciences, University of Nebraska---Lincoln, Lincoln, Nebraska 685831; Department of Veterinary Science, South Dakota State University, Brookings, South Dakota 570072; and Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 537063

Received 27 March 1998/Returned for modification 18 May 1998/Accepted 16 July 1998

Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

* Corresponding author. Mailing address: 111 VBS, University of Nebraska---Lincoln, Fair St. and East Campus Loop, Lincoln, NE 68583-0905. Phone: (402) 472-8460. Fax: (402) 472-9690. E-mail: vets044{at}unlvm.unl.edu.

dagger Published as journal series no. 12184 of the Agricultural Research Division, University of Nebraska.

Dagger Present address: Department of Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI 48109.

Infection and Immunity, October 1998, p. 5031-5035, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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