This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bosio, C. M.
Right arrow Articles by Orme, I. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bosio, C. M.
Right arrow Articles by Orme, I. M.

 Previous Article

Infection and Immunity, October 1998, p. 5048-5051, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effective, Nonsensitizing Vaccination with Culture Filtrate Proteins against Virulent Mycobacterium bovis Infections in Mice

Catharine M. Bosio,* and Ian M. Orme

Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523

Received 14 January 1998/Returned for modification 23 March 1998/Accepted 7 July 1998

Vaccination of mice with Mycobacterium bovis culture filtrate proteins (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl ammonium bromide [DDA]), provided significant protection against an aerosol challenge of virulent M. bovis. Additionally, vaccination with CFP in DDA or Quil-A did not sensitize mice to M. bovis purified protein derivative.

* Corresponding author. Present address: Laboratory of Mycobacteria, Division of Bacterial Products, CBER/FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852. Phone: (301) 496-5850. Fax: (301) 402-2776. E-mail: bosio{at}cber.fda.gov.

Infection and Immunity, October 1998, p. 5048-5051, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wedlock, D. N., Denis, M., Skinner, M. A., Koach, J., de Lisle, G. W., Vordermeier, H. M., Hewinson, R. G., van Drunen Littel-van den Hurk, S., Babiuk, L. A., Hecker, R., Buddle, B. M. (2005). Vaccination of Cattle with a CpG Oligodeoxynucleotide-Formulated Mycobacterial Protein Vaccine and Mycobacterium bovis BCG Induces Levels of Protection against Bovine Tuberculosis Superior to Those Induced by Vaccination with BCG Alone. Infect. Immun. 73: 3540-3546 [Abstract] [Full Text]  
  • Romano, M., Denis, O., D'Souza, S., Wang, X.-M., Ottenhoff, T. H. M., Brulet, J.-M., Huygen, K. (2004). Induction of In Vivo Functional Db-Restricted Cytolytic T Cell Activity against a Putative Phosphate Transport Receptor of Mycobacterium tuberculosis. J. Immunol. 172: 6913-6921 [Abstract] [Full Text]  
  • Skinner, M. A., Buddle, B. M., Wedlock, D. N., Keen, D., de Lisle, G. W., Tascon, R. E., Candido Ferraz, J., Lowrie, D. B., Cockle, P. J., Vordermeier, H. M., Glyn Hewinson, R. (2003). A DNA Prime-Mycobacterium bovis BCG Boost Vaccination Strategy for Cattle Induces Protection against Bovine Tuberculosis. Infect. Immun. 71: 4901-4907 [Abstract] [Full Text]  
  • Wedlock, D. N., Vesosky, B., Skinner, M. A., de Lisle, G. W., Orme, I. M., Buddle, B. M. (2000). Vaccination of Cattle with Mycobacterium bovis Culture Filtrate Proteins and Interleukin-2 for Protection against Bovine Tuberculosis. Infect. Immun. 68: 5809-5815 [Abstract] [Full Text]  
  • Brandt, L., Elhay, M., Rosenkrands, I., Lindblad, E. B., Andersen, P. (2000). ESAT-6 Subunit Vaccination against Mycobacterium tuberculosis. Infect. Immun. 68: 791-795 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»