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Infection and Immunity, November 1998, p. 5565-5569, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Structural and Antigenic Characteristics of Streptococcus sobrinus Glucan Binding Proteins

Daniel J. Smith,1,* William F. King,1 Christine D. Wu,2,dagger Bella I Shen,1 and Martin A. Taubman1

Department of Immunology, Forsyth Dental Center, Boston, Massachusetts 02115,1 and Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 606122

Received 4 May 1998/Returned for modification 8 June 1998/Accepted 20 August 1998

Three purified glucan binding proteins (GBP-2, GBP-3, and GBP-5) from Streptococcus sobrinus 6715 were compared structurally by mass spectroscopy of tryptic fragments and antigenically by Western blot analysis with rat antisera to each GBP or to peptides containing putative glucan binding epitopes of mutans streptococcal glucosyltransferases. Structural and antigenic analyses indicated that GBP-3 and GBP-5 are very similar but that both are essentially unrelated to GBP-2. None of these S. sobrinus GBPs appeared to have a strong antigenic relationship with GBPs from Streptococcus mutans. Thus, S. sobrinus GBP-2 and GBP-3 appear to be distinct proteins with potentially different functions. S. sobrinus GBP-5 may be a proteolytic fragment of GBP-3, or, alternatively, the genes coding for these proteins may be closely related.

* Corresponding author. Mailing address: Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, MA 02115. Phone: (617) 262-5200, ext. 309. Fax: (617) 262-4021. E-mail: dsmith{at}forsyth.org.

dagger This author has previously published under the name Christine D. Wu-Yuan.

Infection and Immunity, November 1998, p. 5565-5569, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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