IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onderdonk, A. B.
Right arrow Articles by Taurog, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onderdonk, A. B.
Right arrow Articles by Taurog, J. D.

 Previous Article  |  Next Article 

Infection and Immunity, December 1998, p. 6022-6023, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Correlation of Cecal Microflora of HLA-B27 Transgenic Rats with Inflammatory Bowel Disease

Andrew B. Onderdonk,1,* James A. Richardson,2 Robert E. Hammer,3 and Joel D. Taurog4

Channing Laboratory, Departments of Medicine and Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,1 and Department of Pathology, Howard Hughes Medical Institute2 and Department of Biochemistry,3 and Harold C. Simmons Arthritis Research Center and Department of Internal Medicine,4 University of Texas Southwestern Medical Center, Dallas, Texas 75235

Received 1 June 1998/Returned for modification 13 July 1998/Accepted 23 September 1998

Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of the cecal microflora showed a rise in numbers of Escherichia coli and Enterococcus spp., corresponding to the presence and severity of IBD in these rats.

* Corresponding author. Mailing address: Channing Laboratory, 181 Longwood Ave., Boston, MA 02115. Phone: (617) 732-7372. Fax: (617) 731-1541. E-mail: ABONDERDON{at}BICS.BWH.HARVARD.EDU.

Infection and Immunity, December 1998, p. 6022-6023, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.