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Infection and Immunity, December 1998, p. 6024-6026, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Sialic Acid-Dependent Recognition of Laminin by Penicillium marneffei Conidia

A. J. Hamilton,1,2,* L. Jeavons,1,2 S. Youngchim,2 N. Vanittanakom,2 and R. J. Hay1

Dunhill Dermatology Unit, St John's Institute of Dermatology, Guy's Hospital, London, United Kingdom,1 and Microbiology Department, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand2

Received 12 June 1998/Returned for modification 21 July 1998/Accepted 25 September 1998

Immunofluorescence microscopy demonstrated that laminin bound to the surface of Penicillium marneffei conidia. Attachment of P. marneffei conidia in an adherence assay was inhibited by soluble laminin and anti-laminin antibody. N-Acetylneuraminic acid abolished adherence, indicating an interaction mediated by a sialic acid-specific lectin.


* Corresponding author. Mailing address: Dunhill Dermatology Unit, St John's Institute of Dermatology, 5th Floor, Thomas Guy House, Guy's Hospital, London SE1 9RT, United Kingdom. Phone: 0171 955 4663. Fax: 0171 407 6689. E-mail: a.hamilton{at}umds.ac.uk.


Infection and Immunity, December 1998, p. 6024-6026, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



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