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Infect Immun, February 1998, p. 756-759, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Secretory Immune Response to Membrane Antigens during Giardia lamblia Infection in Humans

Disney M. Rosales-Borjas,1,2 Juan Díaz-Rivadeneyra,1 Antonio Doña-Leyva,3 Sergio A. Zambrano-Villa,4 Carmen Mascaró,1 Antonio Osuna,1 and Librado Ortiz-Ortiz1,5,*

Grupo de Bioquímica y Parasitología Molecular, Instituto de Biotecnología, Universidad de Granada,1 and EMASAGRA,3 Granada, Spain; Hospital Universitario Dr. Miguel Oraá, Guanare, Edo. Portuguesa, Venezuela2; and Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Guadalajara, Jalisco,4 and Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico, D.F.,5 Mexico

Received 11 July 1997/Returned for modification 12 August 1997/Accepted 13 November 1997

The secretory immune response in humans infected with Giardia lamblia was studied by using saliva samples and a membrane-rich protein fraction. The membrane fraction, studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, showed 24 antigen bands, ranging from 170 to 14 kDa. Saliva samples from giardiasis patients showed a heterogeneous response against the membrane fraction when they were assayed by immunoblotting. Among the antigens recognized by patient saliva samples, those of 170, 105, 92, 66, 32, 29, and 14 kDa stood out. These antigens were not recognized by saliva samples from healthy individuals. They may be of importance in future studies of protection from or diagnosis of G. lamblia infections.

* Corresponding author. Mailing address: Department of Immunology, Instituto de Investigaciones Biomédicas, UNAM, Apartado Postal 70228, 04510 México, D.F., Mexico. Phone: (52 5) 622 3890. Fax: (52 5) 550 0048.




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