This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasaki, S.
Right arrow Articles by Okuda, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasaki, S.
Right arrow Articles by Okuda, K.

 Previous Article  |  Next Article 

Infect Immun, February 1998, p. 823-826, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of Intranasal and Intramuscular Immunization against Human Immunodeficiency Virus Type 1 with a DNA-Monophosphoryl Lipid A Adjuvant Vaccine

Shin Sasaki,1,2 Kenji Hamajima,1 Jun Fukushima,1 Atsushi Ihata,2 Norihisa Ishii,3 Itsuo Gorai,4 Fumiki Hirahara,4 Hiroshi Mohri,2 and Kenji Okuda1,*

Departments of Bacteriology,1 First Internal Medicine,2 Dermatology,3 and Obstetrics and Gynecology,4 Yokohama City University School of Medicine, Yokohama 236, Japan

Received 10 July 1997/Returned for modification 2 September 1997/Accepted 17 November 1997

We compared immune responses to intranasal and intramuscular DNA vaccinations against human immunodeficiency virus type 1 with monophosphoryl lipid A (MPL) used as an adjuvant. Both routes of vaccination resulted in similar levels of cell-mediated immunity, but the intestinal secretory immunoglobulin A response was higher following intranasal immunization than after intramuscular immunization. MPL demonstrated its adjuvanticity in vaccination by both routes.

* Corresponding author. Mailing address: Department of Bacteriology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236, Japan. Phone: 81-45-787-2602. Fax: 81-45-787-2509. E-mail: kokuda{at}med.yokohama-cu.ac.jp.




This article has been cited by other articles:

  • Kaminski, R. W., Turbyfill, K. R., Chao, C., Ching, W. M., Oaks, E. V. (2009). Mucosal Adjuvanticity of a Shigella Invasin Complex with DNA-Based Vaccines. CVI 16: 574-586 [Abstract] [Full Text]  
  • Fan, M.W., Bian, Z., Peng, Z.X., Zhong, Y., Chen, Z., Peng, B., Jia, R. (2002). A DNA Vaccine Encoding a Cell-surface Protein Antigen of Streptococcus mutans Protects Gnotobiotic Rats from Caries. JDR 81: 784-787 [Abstract] [Full Text]  
  • Yang, Q.-B., Martin, M., Michalek, S. M., Katz, J. (2002). Mechanisms of Monophosphoryl Lipid A Augmentation of Host Responses to Recombinant HagB from Porphyromonas gingivalis. Infect. Immun. 70: 3557-3565 [Abstract] [Full Text]  
  • D'Souza, S., Rosseels, V., Denis, O., Tanghe, A., De Smet, N., Jurion, F., Palfliet, K., Castiglioni, N., Vanonckelen, A., Wheeler, C., Huygen, K. (2002). Improved Tuberculosis DNA Vaccines by Formulation in Cationic Lipids. Infect. Immun. 70: 3681-3688 [Abstract] [Full Text]  
  • Childers, N. K., Miller, K. L., Tong, G., Llarena, J. C., Greenway, T., Ulrich, J. T., Michalek, S. M. (2000). Adjuvant Activity of Monophosphoryl Lipid A for Nasal and Oral Immunization with Soluble or Liposome-Associated Antigen. Infect. Immun. 68: 5509-5516 [Abstract] [Full Text]  
  • Kusakabe, K.-i., Xin, K.-Q., Katoh, H., Sumino, K., Hagiwara, E., Kawamoto, S., Okuda, K., Miyagi, Y., Aoki, I., Nishioka, K., Klinman, D., Okuda, K. (2000). The Timing of GM-CSF Expression Plasmid Administration Influences the Th1/Th2 Response Induced by an HIV-1-Specific DNA Vaccine. J. Immunol. 164: 3102-3111 [Abstract] [Full Text]  
  • Dupuy, C., Buzoni-Gatel, D., Touze, A., Bout, D., Coursaget, P. (1999). Nasal Immunization of Mice with Human Papillomavirus Type 16 (HPV-16) Virus-Like Particles or with the HPV-16 L1 Gene Elicits Specific Cytotoxic T Lymphocytes in Vaginal Draining Lymph Nodes. J. Virol. 73: 9063-9071 [Abstract] [Full Text]  
  • Sasaki, S., Sumino, K., Hamajima, K., Fukushima, J., Ishii, N., Kawamoto, S., Mohri, H., Kensil, C. R., Okuda, K. (1998). Induction of Systemic and Mucosal Immune Responses to Human Immunodeficiency Virus Type 1 by a DNA Vaccine Formulated with QS-21 Saponin Adjuvant via Intramuscular and Intranasal Routes. J. Virol. 72: 4931-4939 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»