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Infect Immun, February 1998, p. 830-834, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Protection against Mycobacterium tuberculosis Infection by CD8+ T Cells Requires the Production of Gamma Interferon

Ricardo E. Tascon, Evangelos Stavropoulos, Katalin V. Lukacs,dagger and M. Joseph Colston*

National Institute for Medical Research, London NW7 1AA, United Kingdom

Received 7 July 1997/Returned for modification 22 August 1997/Accepted 29 October 1997

The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex class II knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were incapable of making gamma interferon (IFN-gamma ), it was shown that IFN-gamma production was essential for CD8 cell mediation of protective immunity against M. tuberculosis.

* Corresponding author. Mailing address: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom. Phone: 0181 959 3666, ext. 2354. Fax: 0181 913 8528. E-mail: jcolst.{at}nimr.mrc.ac.uk.

dagger Present address: Ion Transport Unit, National Heart and Lung Institute, London SW3 6LR, United Kingdom.




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