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Infect Immun, March 1998, p. 1248-1251, Vol. 66, No. 3
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

Klaus Kurtenbach,1,2,* Henna-Sisko Sewell,1,2 Nick H. Ogden,3 Sarah E. Randolph,1 and Patricia A. Nuttall2

Department of Zoology, University of Oxford, Oxford OX1 3PS,1 NERC Institute of Virology and Environmental Microbiology, Oxford OX1 3SR,2 and Department of Veterinary Clinical Medicine, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX,3 United Kingdom

Received 15 October 1997/Returned for modification 17 November 1997/Accepted 10 December 1997

The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.

* Corresponding author. Mailing address: The Wellcome Trust Centre for the Epidemiology of Infectious Diseases, Department of Zoology, University of Oxford, South Parks Rd., Oxford OX1 3PS, United Kingdom. Phone: 44-1865-281630. Fax: 44-1865-281696. E-mail: kku{at}mail.nerc-oxford.ac.uk.




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