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Infect Immun, March 1998, p. 1273-1275, Vol. 66, No. 3
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Acute Neutropenia Decreases Inflammation Associated with Murine Vaginal Candidiasis but Has No Effect on the Course of Infection

C. Allen Black,1 Fiona M. Eyers,2 Adrian Russell,1 Margaret L. Dunkley,2 Robert L. Clancy,1 and Kenneth W. Beagley1,*

Discipline of Pathology, University of Newcastle, Callaghan, New South Wales 2308,1 and Australian Institute of Mucosal Immunology, Newcastle, New South Wales 2300,2 Australia

Received 13 January 1997/Returned for modification 27 February 1997/Accepted 29 December 1997

We have used a mouse model of vaginal candidiasis to determine the effect of neutrophil depletion on (a) the clearance of Candida albicans and (b) the degree of inflammation associated with infection. No differences in recoverable yeast number or rate of clearance were observed between normal and neutrophil-depleted mice; however, vaginal inflammation was significantly decreased in neutrophil-depleted animals.

* Corresponding author. Mailing address: Discipline of Pathology, University of Newcastle, Callaghan, NSW 2308, Australia. Phone: 61 (02) 4923-6157. Fax: 61 (02) 4929-2591. E-mail: mdkwb{at}mail.newcastle.edu.au.




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