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Infect Immun, May 1998, p. 2319-2322, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Production of Monocyte Chemoattractant Protein 1 in Tuberculosis Patients

YuanGuang Lin,1 JianHua Gong,2 Ming Zhang,2 Wanfen Xue,3 and Peter F. Barnes2,4,5,*

Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 900331; Center for Pulmonary and Infectious Disease Control,2 Department of Cell Biology,4 and Department of Medicine,5 The University of Texas Health Center, Tyler, Texas 75710; and Department of Pathology, Nanjing Medical University, Nanjing, People's Republic of China3

Received 17 December 1997/Returned for modification 2 February 1998/Accepted 12 February 1998

To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis patients was also markedly increased. These findings suggest that MCP-1 can contribute to the antimycobacterial inflammatory response by attracting monocytes and T lymphocytes.

* Corresponding author. Mailing address: Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center, P.O. Box 2003, Tyler, TX 75710. Phone: (903) 877-5956. Fax: (903) 877-7989. E-mail: pbarnes{at}uthct.edu.

Infect Immun, May 1998, p. 2319-2322, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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