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Infect Immun, May 1998, p. 2346-2348, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Proteins Encoded by the cag Pathogenicity Island of Helicobacter pylori Are Required for NF-kappa B Activation

Erik Glocker,1,2 Christina Lange,3 Antonello Covacci,3 Stefan Bereswill,2 Manfred Kist,2 and Heike L. Pahl1,*

Institute for Experimental Cancer Research, Tumor Biology Center, D-79106 Freiburg,1 and Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, 79104 Freiburg,2 Germany, and IRIS-BIOCINE, 53100 Siena, Italy3

Received 3 November 1997/Returned for modification 22 January 1998/Accepted 11 February 1998

Helicobacter pylori is the etiological agent in the development of chronic gastritis, duodenal ulceration, and gastric adenocarcinoma. The difference in virulence between individual strains is reflected in their ability to induce interleukin-8 (IL-8) secretion from gastric epithelial cells. It has been shown that virulence is associated with the presence of a bacterial gene cluster (a pathogenicity island). We have recently demonstrated that H. pylori-mediated IL-8 secretion requires activation of the transcription factor NF-kappa B. Here, we show that NF-kappa B induction requires six membrane proteins encoded within the pathogenicity island.

* Corresponding author. Mailing address: Institute for Experimental Cancer Research, Tumor Biology Center, P.O. Box 1120, D-79106 Freiburg, Germany. Phone: 49-761-206 1530. Fax: 49-761-206 1599. E-mail: pahl{at}sun2.ruf.uni-freiburg.de.

Infect Immun, May 1998, p. 2346-2348, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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