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Infect Immun, May 1998, p. 2349-2351, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Differential Effects of Gamma Interferon on Chlamydia trachomatis Growth in Polarized and Nonpolarized Human Epithelial Cells in Culture

Colleen D. Kane and Gerald I. Byrne*

Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706

Received 21 November 1997/Returned for modification 20 January 1998/Accepted 16 February 1998

The effects of gamma interferon (IFN-gamma ) on Chlamydia trachomatis growth in polarized epithelial cells were examined. The range of IFN-gamma concentrations causing aberrant chlamydial growth was wider in polarized than in nonpolarized cultures. Results indicate that chlamydial growth modulation in polarized cells readily leads to persistence and better reflects in vivo conditions.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of Wisconsin, 1300 University Ave., Madison, WI 53706. Phone: (608) 263-2494. Fax: (608) 262-8418. E-mail: gibyrne{at}facstaff.wisc.edu.

Infect Immun, May 1998, p. 2349-2351, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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