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Infect Immun, May 1998, p. 2362-2364, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Clot Formation by Group A Streptococci

Haig Donabedian* and Michael D. P. Boyle

Medical College of Ohio, Toledo, Ohio

Received 24 November 1997/Returned for modification 21 January 1998/Accepted 25 February 1998

Group A streptococci of several different M serotypes can cause human plasma to clot in nutrient-poor media. Addition of glucose to the medium prevents clot formation. Once formed, clots are stable for several days and can be lysed on addition of exogenous streptokinase or urokinase. Clot lysis can also be achieved by addition of glucose to a clot containing wild-type group A streptococci but not clots containing an isogenic mutant in which the ska gene was inactivated.

* Corresponding author. Mailing address: Rm 0007-K, 3120 Glendale Avenue, Toledo, OH 43614. Phone: (419) 383-4328. Fax: (419) 383-6244. E-mail: hdonabedian{at}magnum.mco.edu.

Infect Immun, May 1998, p. 2362-2364, Vol. 66, No. 5
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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Copyright © 1998 by the American Society for Microbiology. All rights reserved.