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Infect Immun, June 1998, p. 2984-2986, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Extracellular Release of Antigenic Proteins by Helicobacter pylori

Ping Cao,1 Mark S. McClain,1 Mark H. Forsyth,1 and Timothy L. Cover1,2,3,*

Division of Infectious Diseases, Department of Medicine,1 and Department of Microbiology and Immunology,2 Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605, and Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232-26373

Received 22 December 1997/Returned for modification 13 January 1998/Accepted 3 March 1998

Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracellular space by multiple mechanisms, including specific secretion pathways, autolysis, and membrane vesicle formation.

* Corresponding author. Mailing address: Division of Infectious Diseases, A3310 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232-2605. Phone: (615) 322-2035. Fax: (615) 343-6160. E-mail: COVERTL{at}ctrvax.vanderbilt.edu.

Infect Immun, June 1998, p. 2984-2986, Vol. 66, No. 6
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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