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Infect Immun, July 1998, p. 3433-3435, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Tube Phagocytosis, a Novel Way for Neutrophils To Phagocytize Borrelia burgdorferi

Juha Suhonen,1,* Kaija Hartiala,2 and Matti K. Viljanen3

Department of Medical Microbiology1 and Department of Pediatrics,2 Turku University, and Department in Turku, National Public Health Institute, and Turku Immunology Centre,3 Turku 20520, Finland

Received 3 September 1997/Returned for modification 18 November 1997/Accepted 16 April 1998

Interactions between human neutrophils and Borrelia burgdorferi, the Lyme disease spirochete, were studied by dark-field microscopy combined with video technology. A previously unrecognized mechanism for neutrophils to phagocytize the spirochete was discovered. During phagocytosis, the spirochete attaches to the neutrophil head-on, the neutrophil forms a thin tubelike protrusion around the bacterium, and the fully covered spirochete is drawn into the cell.

* Corresponding author. Mailing address: Department of Medical Microbiology, Turku University, Kiinamyllynkatu 13, Turku 20520, Finland. Phone: 358 2 3337 400. Fax: 358 2 2330 008. E-mail: juha.suhonen{at}utu.fi.

Infect Immun, July 1998, p. 3433-3435, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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