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Infect Immun, July 1998, p. 3449-3453, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Identification of an Insertion Sequence Located in a Region Encoding Virulence Factors of Streptococcus pyogenes

Andreas Berge,* Magnus Rasmussen, and Lars Björck

Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, Lund, Sweden

Received 18 August 1997/Returned for modification 25 November 1997/Accepted 28 April 1998

An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M protein and the C5a peptidase, both important virulence factors. The same or similar insertion sequences were found in most S. pyogenes strains, but the chromosomal location differed among isolates.

* Corresponding author. Mailing address: Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, P.O. Box 94, S-221 00 Lund, Sweden. Phone: 46-46-2224488. Fax: 46-46-157756. E-mail: Andreas.Berge{at}medkem.lu.se.

Infect Immun, July 1998, p. 3449-3453, Vol. 66, No. 7
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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