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Infect Immun, August 1998, p. 3971-3973, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Fab-Independent Antiadhesion Effects of Secretory Immunoglobulin A on S-Fimbriated Escherichia coli Are Mediated by Sialyloligosaccharides

Horst Schroten,1 * Christoph Stapper,1 Ricarda Plogmann,1 Henrik Köhler,1 Jörg Hacker,2 and Franz-Georg Hanisch3

Zentrum für Kinderheilkunde der Heinrich-Heine-Universität, Düsseldorf,1 Institut für Molekulare Infektionsbiologie der Universität Würzburg, Würzburg,2 and Institut für Biochemie II der Universität zu Köln, Köln,3 Germany

Received 16 October 1997/Returned for modification 21 January 1998/Accepted 11 May 1998

S-fimbriated Escherichia coli strains cause sepsis and meningitis in newborns and are known to recognize the carbohydrate sequence sialyl-(alpha 2-3)-galactoside. We show that adhesion of cloned S-fimbriated E. coli to human epithelial cells is inhibited Fab independently by sialyloligosaccharides on secretory immunoglobulin A (s-IgA). This indicates an anti-infective function of s-IgA (Fc), particularly in early human milk.

* Corresponding author. Mailing address: Zentrum für Kinderheilkunde, Heinrich-Heine-Universität, Moorenstr. 5, 40225 Düsseldorf, Germany. Phone: 49-211-8117661. Fax: 49-211-8116266. E-mail: schroten{at}uni-duesseldorf.de.

Infect Immun, August 1998, p. 3971-3973, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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