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Infect Immun, August 1998, p. 3985-3989, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Vag8, a Bordetella pertussis bvg-Regulated Protein

Theresa M. Finn* and Diana F. Amsbaugh

Laboratory of Pertussis, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892

Received 2 February 1998/Returned for modification 23 March 1998/Accepted 9 May 1998

Bordetella pertussis expresses a bvg-regulated 95-kDa protein, Vag8, encoded by vag-8. Southern blot analysis indicates that strains of Bordetella bronchiseptica and Bordetella parapertussis have DNA homologous to vag-8. Antiserum raised to a fusion of maltose binding protein to an N-terminal 60-kDa fragment of Vag8 recognizes the native 95-kDa protein in immunoblots of B. pertussis and B. bronchiseptica but not B. parapertussis. A 95-kDa protein-negative derivative of B. pertussis 18323 containing a deletion of vag-8 colonized mice as efficiently as the parent B. pertussis strain in a mouse aerosol model of pertussis.

* Corresponding author. Mailing address: HFM434, CBER, FDA, 1401 Rockville Pike, Rockville, MD 20852. Phone: (301) 496-2019. Fax: (301) 402-2776. E-mail: finn{at}cber.cber.fda.gov.

Infect Immun, August 1998, p. 3985-3989, Vol. 66, No. 8
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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