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Infection and Immunity, September 1998, p. 4491-4495, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Beta Interferon Is Produced by Chlamydia trachomatis-Infected Fibroblast-Like Synoviocytes and Inhibits Gamma Interferon-Induced HLA-DR Expression

Jürgen Rödel,1,* Annemarie Groh,1 Heinz Vogelsang,2 Marc Lehmann,1 Matthias Hartmann,1 and Eberhard Straube1

Institute of Medical Microbiology1 and Institute of Clinical Immunology,2 Friedrich Schiller University of Jena, D-07743 Jena, Germany

Received 4 March 1998/Returned for modification 13 April 1998/Accepted 17 June 1998

Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-beta ). Chlamydial infection inhibited IFN-gamma -induced expression of HLA-DR antigen in the cells. Addition of IFN-beta antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-beta .

* Corresponding author. Mailing address: Institute of Medical Microbiology, Friedrich Schiller University of Jena, Semmelweisstr. 4, D-07743 Jena, Germany. Phone: 493641/933105. Fax: 493641/933474. E-mail: Roedel{at}BACH.med.uni-jena.de.

Infection and Immunity, September 1998, p. 4491-4495, Vol. 66, No. 9
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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