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Infection and Immunity, January 1999, p. 413-416, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Five Homologous Repeats of the Protein G-Related Protein MIG Cooperate in Binding to Goat Immunoglobulin G

József Vasi,1 Jan Svensson,1,dagger Inga-Maria Frick,2 and Hans-Peter Müller1,3,*

Department of Microbiology, SLU, Uppsala,1 and Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund,2 Sweden and Department of Immunology and Transfusion Medicine, University of Greifswald, Greifswald, Germany3

Received 5 January 1998/Returned for modification 8 April 1998/Accepted 14 October 1998

Protein MIG, from Streptococcus dysgalactiae, binds alpha 2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000-fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.

* Corresponding author. Mailing address: Dept. of Immunology and Transfusion Medicine, Ernst-Moritz-Arndt University, Sauerbruchstr., D-17487 Greifswald, Germany. Phone: 49 3834 865454. Fax: 49 3834 865490. E-mail: Muellerh{at}uni-greifswald.de.

dagger Present address: Department of Plant Biology, SLU, Uppsala, Sweden.

Infection and Immunity, January 1999, p. 413-416, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Song, X.-M., Perez-Casal, J., Fontaine, M. C., Potter, A. A. (2002). Bovine immunoglobulin A (IgA)-binding activities of the surface-expressed Mig protein of Streptococcus dysgalactiae. Microbiology 148: 2055-2064 [Abstract] [Full Text]  
  • Song, X.-M., Perez-Casal, J., Bolton, A., Potter, A. A. (2001). Surface-Expressed Mig Protein Protects Streptococcus dysgalactiae against Phagocytosis by Bovine Neutrophils. Infect. Immun. 69: 6030-6037 [Abstract] [Full Text]  
  • Vasi, J., Frykberg, L., Carlsson, L. E., Lindberg, M., Guss, B. (2000). M-Like Proteins of Streptococcus dysgalactiae. Infect. Immun. 68: 294-302 [Abstract] [Full Text]  


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