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Infection and Immunity, January 1999, p. 417-420, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Increased Levels of Soluble CD14 in Sera of Periodontitis Patients

Joichiro Hayashi,* Tamami Masaka, and Isao Ishikawa

Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan

Received 22 June 1998/Returned for modification 11 August 1998/Accepted 8 October 1998

Soluble CD14 (sCD14) mediates the response to lipopolysaccharide (LPS) in cells lacking membrane-bound CD14. We determined sCD14 concentrations in the sera of 38 periodontitis patients and 25 healthy controls by enzyme-linked immunosorbent assay. The sCD14 levels in the sera of patients with periodontitis were significantly higher than those of healthy subjects and decreased after treatment. Enhanced levels of sCD14 in serum may contribute to the host response to LPS in periodontitis. Furthermore, we showed in vitro that addition of LPS enhanced the release of sCD14 by monoblastic U937 cells treated with 1alpha ,25-dihydroxyvitamin D3. Thus, increased sCD14 levels in periodontitis patients may be due to chronic exposure to LPS.

* Corresponding author. Mailing address: Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan. Phone: 81-3-5803-5488. Fax: 81-3-5803-0196. E-mail: jo-hayashi.peri{at}dent.tmd.ac.jp.

Infection and Immunity, January 1999, p. 417-420, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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