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Infection and Immunity, January 1999, p. 423-425, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Soluble Tumor Necrosis Factor Alpha Receptors in Sera from Leprosy Patients

Martin E. Munk,1,* Peter Anding,1 Antonio P. M. SchettinI,2 Maria da Graça S. Cunha,2 and Stefan H. E. Kaufmann1

Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany,1 and Institute of Tropical Dermatology and Venereology Alfredo da Matta, 69062 Manaus, Brazil2

Received 22 July 1998/Returned for modification 26 August 1998/Accepted 29 October 1998

Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.

* Corresponding author. Mailing address: Max-Planck-Institute for Infection Biology, Monbijoustr. 2, 10117 Berlin, Germany. Phone: 49-30-2802 6587. Fax: 49-30-2802 6212. E-mail: munk{at}mpiib-berlin.mpg.de.

Infection and Immunity, January 1999, p. 423-425, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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