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Infection and Immunity, January 1999, p. 57-63, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Murine gamma delta T Lymphocytes Elicited during Plasmodium yoelii Infection Respond to Plasmodium Heat Shock Proteins

Jeffrey Kopacz, and Nirbhay Kumar*

Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205

Received 22 June 1998/Returned for modification 3 August 1998/Accepted 7 October 1998

gamma delta T cells accumulate during Plasmodium infections in both murine and human malarias. The biological role of these cells and the antigens that they recognize are not clearly understood, although recent findings indicate that gamma delta T cells in general influence both innate and antigen-specific adaptive host responses. We examined the accumulation of gamma delta T cells elicited during infection with virulent and avirulent Plasmodium yoelii parasites in relatively susceptible and resistant strains of mice. Our results indicated that in nonlethal malaria infections, gamma delta T cells comprise a larger proportion of splenic T cells than in lethal infections and that only a live infection is capable of inducing an increase in the percentage of gamma delta T cells in vivo. Furthermore, we demonstrate that gamma delta T cells elicited during a P. yoelii infection respond by proliferation in vitro to P. falciparum heat shock proteins (HSPs) of 60 and 70 kDa, suggesting a possible immunological involvement of parasite HSPs in this arm of the cellular immune response during malarial infection in mice.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205. Phone: (410) 955-7177. Fax: (410) 955-0105. E-mail: nkumar{at}jhsph.edu.

Infection and Immunity, January 1999, p. 57-63, Vol. 67, No. 1
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • SCOTT, C. P., KUMAR, N., BISHAI, W. R., MANABE, Y. C. (2004). SHORT REPORT: MODULATION OF MYCOBACTERIUM TUBERCULOSIS INFECTION BY PLASMODIUM IN THE MURINE MODEL. Am J Trop Med Hyg 70: 144-148 [Abstract] [Full Text]  
  • Sanchez, G. I., Sedegah, M., Rogers, W. O., Jones, T. R., Sacci, J., Witney, A., Carucci, D. J., Kumar, N., Hoffman, S. L. (2001). Immunogenicity and Protective Efficacy of a Plasmodium yoelii Hsp60 DNA Vaccine in BALB/c Mice. Infect. Immun. 69: 3897-3905 [Abstract] [Full Text]  
  • Choudhury, H. R., Sheikh, N. A., Bancroft, G. J., Katz, D. R., de Souza, J. B. (2000). Early Nonspecific Immune Responses and Immunity to Blood-Stage Nonlethal Plasmodium yoelii Malaria. Infect. Immun. 68: 6127-6132 [Abstract] [Full Text]  


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