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Infection and Immunity, October 1999, p. 5243-5246, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Serological Investigation of Chlamydia trachomatis Heat Shock Protein 10

Fotini Betsou,1 Jean Marie Sueur,1,* and Jeanne Orfila2

Biobanque de Picardie1 and Department of Bacteriology, University Hospital,2 Amiens, France

Received 8 April 1999/Returned for modification 9 June 1999/Accepted 6 July 1999

The humoral immune response to Chlamydia trachomatis 10-kDa heat shock protein (Chsp10) in populations of Russian and French origin was studied by using a recombinant Chsp10 enzyme-linked immunosorbent assay. A physiological but not a serological correlation of Chsp10 exposure with Chsp60 exposure was observed in the Russian population. In the French population studied, there was a significant association between detection of anti-r-Chsp10 immunoglobulin G (IgG) antibodies and chronic genital tract infections. Chsp10 residues 50 to 67 were found to contain an immunodominant although not universal B epitope. Cross-reactions with Chlamydia pneumoniae or Escherichia coli GroES protein are limited but may occur. Our study suggests that detection of anti-Chsp10 IgG antibodies is associated with chronicity of C. trachomatis genital tract infection and does not parallel that of anti-Chsp60 IgG antibodies.

* Corresponding author. Mailing address: Biobanque de Picardie, 16 rue Fernel, 80000 Amiens, France. Phone: 330322913967. Fax: 330322916954. E-mail: j57722{at}hotmail.com.

Infection and Immunity, October 1999, p. 5243-5246, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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