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Infection and Immunity, October 1999, p. 5473-5476, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Tumor Necrosis Factor (TNF) and a TNF-Mimetic Peptide Modulate the Granulomatous Response to Mycobacterium bovis BCG Infection In Vivo

D. R. Roach,1 H. Briscoe,1,2 K. Baumgart,1 D. A. Rathjen,3 and W. J. Britton1,2,*

Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042,1 Department of Medicine, University of Sydney, New South Wales 2006,2 and Peptide Technology Limited and Department of Clinical Immunology, Women's and Children's Hospital, Adelaide, South Australia,3 Australia

Received 23 March 1999/Returned for modification 6 May 1999/Accepted 20 July 1999

Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF70-80) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.

* Corresponding author. Mailing address: Centenary Institute, of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, New South Wales 2042, Australia. Phone: 61-2-9515 5210. Fax: 61-2-9351 3968. E-mail: wbritton{at}medicine.usyd.edu.au.

Infection and Immunity, October 1999, p. 5473-5476, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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