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Infection and Immunity, October 1999, p. 5495-5499, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Growth-Phase-Dependent Expression of Virulence Factors in an M1T1 Clinical Isolate of Streptococcus pyogenes

Meera Unnikrishnan, Jonathan Cohen, and Shiranee Sriskandan*

Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom

Received 26 April 1999/Returned for modification 2 June 1999/Accepted 27 July 1999

The effect of growth phase on expression of virulence-associated factors was studied by Northern hybridization in an M1T1 clinical isolate of Streptococcus pyogenes. Expression of M protein, C5a peptidase, and capsule was maximal in the exponential phase of growth, while streptococcal pyrogenic exotoxins A and B and mitogenic factor were maximally expressed in later phases of growth.

* Corresponding author. Mailing address: Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, DuCane Rd., London W12 0NN, United Kingdom. Phone: 44-181-3833135. Fax: 44-181-3833394. E-mail: ssriskan{at}ic.ac.uk.

Infection and Immunity, October 1999, p. 5495-5499, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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