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Infection and Immunity, October 1999, p. 5514-5517, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Chlamydospore Formation in Candida albicans Requires the Efg1p Morphogenetic Regulator

Anja Sonneborn, Dirk P. Bockmühl, and Joachim F. Ernst*

Institut für Mikrobiologie, Heinrich-Heine-Universität, D-40225 Düsseldorf, Germany

Received 29 March 1999/Returned for modification 10 June 1999/Accepted 30 June 1999

Chlamydospore formation of the fungal pathogen Candida albicans was found to depend on the Efg1 protein, which regulates the yeast-hyphal transition. Isogenic mutants lacking EFG1 or encoding T206A and T206E variants did not differentiate chlamydospores, while cek1, cph1, or tpk2 mutations had no effect. Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions suggests a novel Efg1p/Cph1p-independent filamentation pathway in C. albicans.

* Corresponding author. Mailing address: Institut für Mikrobiologie, Heinrich-Heine-Universität, Universitätsstr. 1/26.12, D-40225 Düsseldorf, Germany. Phone and fax: 49 (211) 811 5176. E-mail: joachim.ernst{at}uni-duesseldorf.de.

Infection and Immunity, October 1999, p. 5514-5517, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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