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Infection and Immunity, October 1999, p. 5518-5521, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection

James I. Ito* and Joseph M. Lyons

Department of Infectious Diseases, City of Hope National Medical Center, Duarte, California 91010

Received 6 August 1998/Returned for modification 30 September 1998/Accepted 7 July 1999

Earlier investigations have not shown an important role for gamma interferon (IFN-gamma ) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.

* Corresponding author. Mailing address: Department of Infectious Diseases, City of Hope National Medical Center, 1500 E. Duarte Rd., Duarte, CA 91010. Phone: (626) 359-8111. Fax: (626) 301-8954. E-mail: jito{at}coh.org.

Infection and Immunity, October 1999, p. 5518-5521, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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