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Infection and Immunity, November 1999, p. 5811-5814, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Consequence of Nramp1 Deletion to Mycobacterium tuberculosis Infection in Mice

Robert J. North,1,* Ronald LaCourse,1 Lynn Ryan,1 and Philippe Gros2

The Trudeau Institute, Saranac Lake, New York 12983,1 and Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y62

Received 18 June 1999/Returned for modification 5 August 1999/Accepted 24 August 1999

129sv mice functionally deleted of the antimicrobial resistance gene, Nramp1, were found to be as resistant as wild-type mice to infection with the virulent H37Rv strain of Mycobacterium tuberculosis, as determined by monitoring bacterial growth in major organs and recording host survival times. Death of infected mice of both types was associated with extensive infection-induced pathology in the lungs but not in other major organs. These findings are in keeping with the view that Nramp1 is of limited importance in resistance to tuberculosis in mice.

* Corresponding author. Mailing address: The Trudeau Institute, 100 Algonquin Ave., Saranac Lake, NY 12983. Phone: (518) 891-3080. Fax: (518) 891-5126. E-mail: rjnorth{at}northnet.org.

Infection and Immunity, November 1999, p. 5811-5814, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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