This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, J.
Right arrow Articles by Kondo, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, J.
Right arrow Articles by Kondo, H.

 Previous Article  |  Next Article 

Infection and Immunity, November 1999, p. 6203-6205, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of Neutrophil Apoptosis by Verotoxin 2 Derived from Escherichia coli O157:H7

Jiajia Liu, Tohru Akahoshi,* Takeshi Sasahana, Hidero Kitasato, Rie Namai, Takeji Sasaki, Matsuhisa Inoue, and Hirobumi Kondo

Department of Internal Medicine and Microbiology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228-8555, Japan

Received 6 July 1999/Returned for modification 30 July 1999/Accepted 20 August 1999

In order to evaluate the pathological role of verotoxin 2 (VT2), we investigated the effects of VT2 on neutrophil apoptosis in vitro. The results showed that VT2 caused a significant delay in spontaneous neutrophil apoptosis and that the effect was abrogated by a protein kinase C inhibitor. These data indicate that longer survival of neutrophils may aggravate neutrophil-mediated tissue damage in VT2-associated diseases.

* Corresponding author. Mailing address: Department of Internal Medicine and Microbiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. Phone: 42-778-9347. Fax: 42-778-8441. E-mail: akahoshi{at}med.kitasato-u.ac.jp.

Infection and Immunity, November 1999, p. 6203-6205, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Brigotti, M., Carnicelli, D., Ravanelli, E., Barbieri, S., Ricci, F., Bontadini, A., Tozzi, A. E., Scavia, G., Caprioli, A., Tazzari, P. L. (2008). Interactions between Shiga toxins and human polymorphonuclear leukocytes. J. Leukoc. Biol. 84: 1019-1027 [Abstract] [Full Text]  
  • Griener, T. P., Mulvey, G. L., Marcato, P., Armstrong, G. D. (2007). Differential binding of Shiga toxin 2 to human and murine neutrophils. J Med Microbiol 56: 1423-1430 [Abstract] [Full Text]  
  • Geelen, J. M., van der Velden, T. J. A. M., te Loo, D. M. W. M., Boerman, O. C., van den Heuvel, L. P. W. J., Monnens, L. A. H. (2007). Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes. Nephrol Dial Transplant 22: 749-755 [Abstract] [Full Text]  
  • Flagler, M. J., Strasser, J. E., Chalk, C. L., Weiss, A. A. (2007). Comparative Analysis of the Abilities of Shiga Toxins 1 and 2 To Bind to and Influence Neutrophil Apoptosis. Infect. Immun. 75: 760-765 [Abstract] [Full Text]  
  • Brigotti, M., Caprioli, A., Tozzi, A. E., Tazzari, P. L., Ricci, F., Conte, R., Carnicelli, D., Procaccino, M. A., Minelli, F., Ferretti, A. V. S., Paglialonga, F., Edefonti, A., Rizzoni, G. (2006). Shiga Toxins Present in the Gut and in the Polymorphonuclear Leukocytes Circulating in the Blood of Children with Hemolytic-Uremic Syndrome. J. Clin. Microbiol. 44: 313-317 [Abstract] [Full Text]  
  • Harrison, L. M., van den Hoogen, C., van Haaften, W. C. E., Tesh, V. L. (2005). Chemokine Expression in the Monocytic Cell Line THP-1 in Response to Purified Shiga Toxin 1 and/or Lipopolysaccharides. Infect. Immun. 73: 403-412 [Abstract] [Full Text]  
  • Blomgran, R., Zheng, L., Stendahl, O. (2004). Uropathogenic Escherichia coli Triggers Oxygen-Dependent Apoptosis in Human Neutrophils through the Cooperative Effect of Type 1 Fimbriae and Lipopolysaccharide. Infect. Immun. 72: 4570-4578 [Abstract] [Full Text]  
  • Cameron, P., Bingham, D., Paul, A., Pavelka, M., Cameron, S., Rotondo, D., Plevin, R. (2002). Essential Role for Verotoxin in Sustained Stress-Activated Protein Kinase and Nuclear Factor Kappa B Signaling, Stimulated by Escherichia coli O157:H7 in Vero Cells. Infect. Immun. 70: 5370-5380 [Abstract] [Full Text]  
  • TE LOO, D. M. W. M., HINSBERGH, V. W. M. V., HEUVEL, L. P. W. J. V. D., MONNENS, L. A. H. (2001). Detection of Verocytotoxin Bound to Circulating Polymorphonuclear Leukocytes of Patients with Hemolytic Uremic Syndrome. J. Am. Soc. Nephrol. 12: 800-806 [Abstract] [Full Text]  
  • Wagner, P. L., Acheson, D. W. K., Waldor, M. K. (2001). Human Neutrophils and Their Products Induce Shiga Toxin Production by Enterohemorrhagic Escherichia coli. Infect. Immun. 69: 1934-1937 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»