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 Previous Article

Infection and Immunity, November 1999, p. 6221-6224, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Differential Expression of Caprine beta -Defensins in Digestive and Respiratory Tissues

Chengquan Zhao,1 Tung Nguyen,1 Lide Liu,1 Olga Shamova,1,2 Kim Brogden,3 and Robert I. Lehrer1,4,*

Department of Medicine1 and Molecular Biology Institute,4 UCLA School of Medicine, Los Angeles, California 90095, Institute for Experimental Medicine, St. Petersburg, Russia,2 and Respiratory and Neurologic Diseases Research Unit, Midwest Area National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 500103

Received 5 April 1999/Returned for modification 28 May 1999/Accepted 6 August 1999

We identified two novel beta -defensin precursors, preproGBD-1 and preproGBD-2, in the tissues of a goat. Although the precursors were identical in 96.8% of their bases and 88.2% (60 of 68) of their amino acids, preproGBD-1 was expressed principally in the tongue and respiratory tract, whereas preproGBD-2 expression predominated throughout the intestine. These findings exemplify the phenomenon of tissue-specific expression in a family of host defense peptides that arose before the avian and mammalian lineages diverged.

* Corresponding author. Mailing address: Department of Medicine, Room CHS 37-062, UCLA School of Medicine, 10833 LeConte Ave., Los Angeles, CA 90095-1690. Phone: (310) 825-5340. Fax: (310) 206-8766. E-mail: rlehrer{at}med1.medsch.ucla.edu.

Infection and Immunity, November 1999, p. 6221-6224, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Cunliffe, R. N., Mahida, Y. R. (2004). Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J. Leukoc. Biol. 75: 49-58 [Abstract] [Full Text]  


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