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Infection and Immunity, December 1999, p. 6691-6694, Vol. 67, No. 12
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Attenuated Expression of the mga Virulence Regulon in an M Serotype 50 Mouse-Virulent Group A Streptococcal Strain

Der-Li Yung,1 Kevin S. McIver,2 June R. Scott,2 and Susan K. Hollingshead1,*

Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294,1 and Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 303222

Received 10 June 1999/Returned for modification 13 August 1999/Accepted 13 September 1999

The attenuated expression of virulence genes found in a group A streptococcal strain that is naturally pathogenic for mice was postulated to result from a defect in the strain's multigene regulator, Mga. The sequence of the mga gene reveals three amino acid changes in the gene product that might affect protein function. The defect in the mga gene was complemented by providing either the closely similar mga4 allele or a more divergent mga1 allele in trans. Complementation increased the amount of emm50 transcript and the quantity of surface-extractable M protein, restoring virulence function.

* Corresponding author. Mailing address: Dept. of Microbiology, BBRB 654/25, University of Alabama at Birmingham, 845 19th St. South, Birmingham, AL 35294. Phone: (205) 934-0570. Fax: (205) 975-5480. E-mail: hollings{at}uab.edu.

Infection and Immunity, December 1999, p. 6691-6694, Vol. 67, No. 12
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Vahling, C. M., McIver, K. S. (2005). Identification of Residues Responsible for the Defective Virulence Gene Regulator Mga Produced by a Natural Mutant of Streptococcus pyogenes. J. Bacteriol. 187: 5955-5966 [Abstract] [Full Text]  
  • Limbago, B., McIver, K. S., Penumalli, V., Weinrick, B., Scott, J. R. (2001). Restoration of Mga Function to a Streptococcus pyogenes Strain (M Type 50) That Is Virulent in Mice. Infect. Immun. 69: 1215-1220 [Abstract] [Full Text]  


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