This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Darmstadt, G. L.
Right arrow Articles by Rubens, C. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Darmstadt, G. L.
Right arrow Articles by Rubens, C. E.

 Previous Article  |  Next Article 

Infection and Immunity, December 1999, p. 6707-6709, Vol. 67, No. 12
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Role of Keratinocyte Injury in Adherence of Streptococcus pyogenes

Gary L. Darmstadt,1,2,3 Laurel Mentele,1 Philip Fleckman,2 and Craig E. Rubens1,*

Divisions of Infectious Diseases1 and Dermatology,2 Department of Pediatrics, Children's Hospital & Regional Medical Center, and Division of Dermatology, Department of Medicine, University of Washington School of Medicine,3 Seattle, Washington 98105

Received 2 July 1999/Returned for modification 12 August 1999/Accepted 30 September 1999

Keratinocytes injured acutely by UVB light or lipopolysaccharide were used to test the hypothesis that keratinocyte injury promotes bacterial adherence and the development of group A streptococcal skin infections. Injury did not affect adherence to undifferentiated and differentiated keratinocytes, but keratinocyte differentiation promoted adherence four- to fivefold.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Pediatrics CH-32, Children's Hospital & Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105. Phone: (206) 526-2073. Fax: (206) 527-3890. E-mail: cruben{at}chmc.org.

Infection and Immunity, December 1999, p. 6707-6709, Vol. 67, No. 12
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Dinulos, J. G. H., Mentele, L., Fredericks, L. P., Dale, B. A., Darmstadt, G. L. (2003). Keratinocyte Expression of Human {beta} Defensin 2 following Bacterial Infection: Role in Cutaneous Host Defense. CVI 10: 161-166 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»