This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mastroeni, P.
Right arrow Articles by Dougan, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mastroeni, P.
Right arrow Articles by Dougan, G.

 Previous Article  |  Next Article 

Infection and Immunity, February 1999, p. 478-483, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with Virulent Salmonella typhimurium

Pietro Mastroeni,1,* S. Clare,1 S. Khan,2 J. A. Harrison,3 C. E. Hormaeche,3 H. Okamura,4 M. Kurimoto,5 and G. Dougan1

Department of Biochemistry, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ,1 School of Microbiological, Immunological and Virological Sciences, Medical School, University of Newcastle, Newcastle Upon Tyne NE2 4HH,3 and Department of Clinical Veterinary Medicine, Madingley Road, Cambridge CB3 OES,2 United Kingdom, and Hyogo College of Medicine, Nishinomiya,4 and Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Okayama,5 Japan

Received 24 April 1998/Returned for modification 10 June 1998/Accepted 10 November 1998

Spleen and peritoneal macrophages obtained from innately resistant A/J mice released low levels of interleukin 18 (IL-18) upon infection with Salmonella typhimurium C5 RP4. Incubating the cells with recombinant gamma interferon (rIFN-gamma ) enhanced IL-18 production. A/J mice treated in vivo with anti-IL-18 antibodies showed impaired resistance to infection, with increased bacterial loads in the liver and spleen. Administration of rIL-18 could protect A/J mice from challenge with a lethal dose of virulent salmonellae, with a dramatic reduction in bacterial numbers in the tissues. rIL-18 administration did not ameliorate the disease in IFN-gamma -R-/- mice. IL-18 proved to be required for IFN-gamma production by mouse splenocytes from conventional, scid, and rag-1-/- mice; in vivo IL-18 neutralization caused a decrease in circulating IFN-gamma levels. Thus, IL-18 is a key factor in early host resistance to Salmonella and probably acts via IFN-gamma .

* Corresponding author. Mailing address: Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Rd., South Kensington, London SW7 2AZ, United Kingdom. Phone: 44 171 594 5254. Fax: 44 171 594 5255. E-mail: p.mastroeni{at}ic.ac.uk.

Infection and Immunity, February 1999, p. 478-483, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wan, Y. Y., Flavell, R. A. (2009). How Diverse--CD4 Effector T Cells and their Functions. J Mol Cell Biol 1: 20-36 [Abstract] [Full Text]  
  • Haring, J. S., Harty, J. T. (2009). Interleukin-18-Related Genes Are Induced during the Contraction Phase but Do Not Play Major Roles in Regulating the Dynamics or Function of the T-Cell Response to Listeria monocytogenes Infection. Infect. Immun. 77: 1894-1903 [Abstract] [Full Text]  
  • Lochner, M., Kastenmuller, K., Neuenhahn, M., Weighardt, H., Busch, D. H., Reindl, W., Forster, I. (2008). Decreased Susceptibility of Mice to Infection with Listeria monocytogenes in the Absence of Interleukin-18. Infect. Immun. 76: 3881-3890 [Abstract] [Full Text]  
  • Berndt, A., Wilhelm, A., Jugert, C., Pieper, J., Sachse, K., Methner, U. (2007). Chicken Cecum Immune Response to Salmonella enterica Serovars of Different Levels of Invasiveness. Infect. Immun. 75: 5993-6007 [Abstract] [Full Text]  
  • Price, J. D., Simpfendorfer, K. R., Mantena, R. R., Holden, J., Heath, W. R., van Rooijen, N., Strugnell, R. A., Wijburg, O. L. C. (2007). Gamma Interferon-Independent Effects of Interleukin-12 on Immunity to Salmonella enterica Serovar Typhimurium. Infect. Immun. 75: 5753-5762 [Abstract] [Full Text]  
  • Wiersinga, W. J., Wieland, C. W., van der Windt, G. J. W., de Boer, A., Florquin, S., Dondorp, A., Day, N. P., Peacock, S. J., van der Poll, T. (2007). Endogenous Interleukin-18 Improves the Early Antimicrobial Host Response in Severe Melioidosis. Infect. Immun. 75: 3739-3746 [Abstract] [Full Text]  
  • Srinivasan, A., Salazar-Gonzalez, R.-M., Jarcho, M., Sandau, M. M., Lefrancois, L., McSorley, S. J. (2007). Innate Immune Activation of CD4 T Cells in Salmonella-Infected Mice Is Dependent on IL-18. J. Immunol. 178: 6342-6349 [Abstract] [Full Text]  
  • Raupach, B., Peuschel, S.-K., Monack, D. M., Zychlinsky, A. (2006). Caspase-1-Mediated Activation of Interleukin-1{beta} (IL-1{beta}) and IL-18 Contributes to Innate Immune Defenses against Salmonella enterica Serovar Typhimurium Infection.. Infect. Immun. 74: 4922-4926 [Abstract] [Full Text]  
  • Maxwell, J. R., Yadav, R., Rossi, R. J., Ruby, C. E., Weinberg, A. D., Aguila, H. L., Vella, A. T. (2006). IL-18 Bridges Innate and Adaptive Immunity through IFN-{gamma} and the CD134 Pathway. J. Immunol. 177: 234-245 [Abstract] [Full Text]  
  • Lara-Tejero, M., Sutterwala, F. S., Ogura, Y., Grant, E. P., Bertin, J., Coyle, A. J., Flavell, R. A., Galan, J. E. (2006). Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. JEM 203: 1407-1412 [Abstract] [Full Text]  
  • van Diepen, A., van de Gevel, J. S., Koudijs, M. M., Ossendorp, F., Beekhuizen, H., Janssen, R., van Dissel, J. T. (2005). Gamma Irradiation or CD4+-T-Cell Depletion Causes Reactivation of Latent Salmonella enterica Serovar Typhimurium Infection in C3H/HeN Mice. Infect. Immun. 73: 2857-2862 [Abstract] [Full Text]  
  • Paterson, G K, Blue, C E, Mitchell, T J (2005). Role of interleukin-18 in experimental infections with Streptococcus pneumoniae. J Med Microbiol 54: 323-326 [Abstract] [Full Text]  
  • Akhiani, A. A., Schon, K., Lycke, N. (2004). Vaccine-Induced Immunity against Helicobacter pylori Infection Is Impaired in IL-18-Deficient Mice. J. Immunol. 173: 3348-3356 [Abstract] [Full Text]  
  • van der Velden, A. W. M., Velasquez, M., Starnbach, M. N. (2003). Salmonella Rapidly Kill Dendritic Cells via a Caspase-1- Dependent Mechanism. J. Immunol. 171: 6742-6749 [Abstract] [Full Text]  
  • Clare, S., Goldin, R., Hale, C., Aspinall, R., Simmons, C., Mastroeni, P., Dougan, G. (2003). Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis. Infect. Immun. 71: 5881-5891 [Abstract] [Full Text]  
  • Foster, N., Hulme, S. D., Barrow, P. A. (2003). Induction of Antimicrobial Pathways during Early-Phase Immune Response to Salmonella spp. in Murine Macrophages: Gamma Interferon (IFN-{gamma}) and Upregulation of IFN-{gamma} Receptor Alpha Expression Are Required for NADPH Phagocytic Oxidase gp91-Stimulated Oxidative Burst and Control of Virulent Salmonella spp.. Infect. Immun. 71: 4733-4741 [Abstract] [Full Text]  
  • Schultz, M. J., Knapp, S., Florquin, S., Pater, J., Takeda, K., Akira, S., van der Poll, T. (2003). Interleukin-18 Impairs the Pulmonary Host Response to Pseudomonas aeruginosa. Infect. Immun. 71: 1630-1634 [Abstract] [Full Text]  
  • Bas, S., Kvien, T. K., Buchs, N., Fulpius, T., Gabay, C. (2003). Lower level of synovial fluid interferon-{gamma} in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. Rheumatology (Oxford) 42: 461-467 [Abstract] [Full Text]  
  • Gracie, J. A., Robertson, S. E., McInnes, I. B. (2003). Interleukin-18. J. Leukoc. Biol. 73: 213-224 [Abstract] [Full Text]  
  • Biet, F., Kremer, L., Wolowczuk, I., Delacre, M., Locht, C. (2002). Mycobacterium bovis BCG Producing Interleukin-18 Increases Antigen-Specific Gamma Interferon Production in Mice. Infect. Immun. 70: 6549-6557 [Abstract] [Full Text]  
  • Joshi, V. D., Kalvakolanu, D. V., Hebel, J. R., Hasday, J. D., Cross, A. S. (2002). Role of Caspase 1 in Murine Antibacterial Host Defenses and Lethal Endotoxemia. Infect. Immun. 70: 6896-6903 [Abstract] [Full Text]  
  • Kirby, A. C., Yrlid, U., Wick, M. J. (2002). The Innate Immune Response Differs in Primary and Secondary Salmonella Infection. J. Immunol. 169: 4450-4459 [Abstract] [Full Text]  
  • Kinjo, Y., Kawakami, K., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Hoshino, T., Okamoto, M., Kawase, Y., Yokota, K., Yoshino, K., Takeda, K., Akira, S., Saito, A. (2002). Contribution of IL-18 to Th1 Response and Host Defense Against Infection by Mycobacterium tuberculosis: A Comparative Study with IL-12p40. J. Immunol. 169: 323-329 [Abstract] [Full Text]  
  • Stuyt, R. J. L., Netea, M. G., Verschueren, I., Fantuzzi, G., Dinarello, C. A., Van der Meer, J. W. M., Kullberg, B. J. (2002). Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection. Infect. Immun. 70: 3284-3286 [Abstract] [Full Text]  
  • Singh, R. P., Kashiwamura, S.-i., Rao, P., Okamura, H., Mukherjee, A., Chauhan, V. S. (2002). The Role of IL-18 in Blood-Stage Immunity Against Murine Malaria Plasmodium yoelii265 and Plasmodium bergheiANKA. J. Immunol. 168: 4674-4681 [Abstract] [Full Text]  
  • Santos, R. L., Zhang, S., Tsolis, R. M., Baumler, A. J., Adams, L. G. (2002). Morphologic and Molecular Characterization of Salmonella typhimurium Infection in Neonatal Calves. Vet Pathol 39: 200-215 [Abstract] [Full Text]  
  • Lauw, F. N., Branger, J., Florquin, S., Speelman, P., van Deventer, S. J. H., Akira, S., van der Poll, T. (2002). IL-18 Improves the Early Antimicrobial Host Response to Pneumococcal Pneumonia. J. Immunol. 168: 372-378 [Abstract] [Full Text]  
  • Kawakami, K., Kinjo, Y., Yara, S., Uezu, K., Koguchi, Y., Tohyama, M., Azuma, M., Takeda, K., Akira, S., Saito, A. (2001). Enhanced Gamma Interferon Production through Activation of Valpha 14+ Natural Killer T Cells by alpha -Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis. Infect. Immun. 69: 6643-6650 [Abstract] [Full Text]  
  • Ogura, T., Ueda, H., Hosohara, K., Tsuji, R., Nagata, Y., Kashiwamura, S.-i., Okamura, H. (2001). Interleukin-18 stimulates hematopoietic cytokine and growth factor formation and augments circulating granulocytes in mice. Blood 98: 2101-2107 [Abstract] [Full Text]  
  • Neighbors, M., Xu, X., Barrat, F. J., Ruuls, S. R., Churakova, T., Debets, R., Bazan, J. F., Kastelein, R. A., Abrams, J. S., O'Garra, A. (2001). A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon {gamma} Production. JEM 194: 343-354 [Abstract] [Full Text]  
  • Harandi, A. M., Svennerholm, B., Holmgren, J., Eriksson, K. (2001). Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity. J. Virol. 75: 6705-6709 [Abstract] [Full Text]  
  • Hanck, C, Manigold, T, Bocker, U, Kurimoto, M, Kolbel, C B, Singer, M V, Rossol, S (2001). Gene expression of interleukin 18 in unstimulated peripheral blood mononuclear cells of patients with alcoholic cirrhosis. Gut 49: 106-111 [Abstract] [Full Text]  
  • Vankayalapati, R., Wizel, B., Lakey, D. L., Zhang, Y., Coffee, K. A., Griffith, D. E., Barnes, P. F. (2001). T Cells Enhance Production of IL-18 by Monocytes in Response to an Intracellular Pathogen. J. Immunol. 166: 6749-6753 [Abstract] [Full Text]  
  • Lertmemongkolchai, G., Cai, G., Hunter, C. A., Bancroft, G. J. (2001). Bystander Activation of CD8+ T Cells Contributes to the Rapid Production of IFN-{{gamma}} in Response to Bacterial Pathogens. J. Immunol. 166: 1097-1105 [Abstract] [Full Text]  
  • Lehner, M. D., Ittner, J., Bundschuh, D. S., van Rooijen, N., Wendel, A., Hartung, T. (2001). Improved Innate Immunity of Endotoxin-Tolerant Mice Increases Resistance to Salmonella enterica Serovar Typhimurium Infection despite Attenuated Cytokine Response. Infect. Immun. 69: 463-471 [Abstract] [Full Text]  
  • Cai, G., Kastelein, R., Hunter, C. A. (2000). Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to Toxoplasma gondii. Infect. Immun. 68: 6932-6938 [Abstract] [Full Text]  
  • Jesenberger, V., Procyk, K. J., Yuan, J., Reipert, S., Baccarini, M. (2000). Salmonella-Induced Caspase-2 Activation in Macrophages: A Novel Mechanism in Pathogen-Mediated Apoptosis. JEM 192: 1035-1046 [Abstract] [Full Text]  
  • Mastroeni, P., Vazquez-Torres, A., Fang, F. C., Xu, Y., Khan, S., Hormaeche, C. E., Dougan, G. (2000). Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. II. Effects on Microbial Proliferation and Host Survival in Vivo. JEM 192: 237-248 [Abstract] [Full Text]  
  • Monack, D. M., Hersh, D., Ghori, N., Bouley, D., Zychlinsky, A., Falkow, S. (2000). Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model. JEM 192: 249-258 [Abstract] [Full Text]  
  • Kawakami, K., Koguchi, Y., Qureshi, M. H., Miyazato, A., Yara, S., Kinjo, Y., Iwakura, Y., Takeda, K., Akira, S., Kurimoto, M., Saito, A. (2000). IL-18 Contributes to Host Resistance Against Infection with Cryptococcus neoformans in Mice with Defective IL-12 Synthesis Through Induction of IFN-{gamma} Production by NK Cells. J. Immunol. 165: 941-947 [Abstract] [Full Text]  
  • Nakamura, S., Otani, T., Ijiri, Y., Motoda, R., Kurimoto, M., Orita, K. (2000). IFN-{gamma}-Dependent and -Independent Mechanisms in Adverse Effects Caused by Concomitant Administration of IL-18 and IL-12. J. Immunol. 164: 3330-3336 [Abstract] [Full Text]  
  • Mastroeni, P., Simmons, C., Fowler, R., Hormaeche, C. E., Dougan, G. (2000). Igh-6-/- (B-Cell-Deficient) Mice Fail To Mount Solid Acquired Resistance to Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium and Show Impaired Th1 T-Cell Responses to Salmonella Antigens. Infect. Immun. 68: 46-53 [Abstract] [Full Text]  
  • Dybing, J. K., Walters, N., Pascual, D. W. (1999). Role of Endogenous Interleukin-18 in Resolving Wild-Type and Attenuated Salmonella typhimurium Infections. Infect. Immun. 67: 6242-6248 [Abstract] [Full Text]  
  • Elhofy, A., Bost, K. L. (1999). Limited Interleukin-18 Response in Salmonella-Infected Murine Macrophages and in Salmonella-Infected Mice. Infect. Immun. 67: 5021-5026 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»