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Infection and Immunity, February 1999, p. 989-993, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Interleukin-5 Transgenic Mice Show Enhanced Resistance to Primary Infections with Nippostrongylus brasiliensis but Not Primary Infections with Toxocara canis

Lindsay A. Dent,1,* Christine M. Daly,1 Graham Mayrhofer,1 Trudy Zimmerman,1 Ann Hallett,1 Leon P. Bignold,2 Jenette Creaney,3 and Jim C. Parsons3

Departments of Microbiology and Immunology1 and Pathology,2 University of Adelaide, Adelaide, South Australia, and Victorian Institute of Animal Science, Attwood, Victoria,3 Australia

Received 2 June 1998/Returned for modification 24 July 1998/Accepted 29 October 1998

In this study, interleukin-5 (IL-5) transgenic mice with lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensis and Toxocara canis. Relative to nontransgenic littermates, three lines of IL-5 transgenic mice with varying degrees of eosinophilia all displayed enhanced resistance to N. brasiliensis. Although the timing of final worm expulsion was similar in transgenic and nontransgenic hosts, intestinal worms in transgenic mice were fewer in number throughout infection, failed to increase in size over the course of the infection, and were much less fecund. In contrast, T. canis larvae were recovered in similar numbers from tissues of transgenic mice with "low" or "high" eosinophilia and from nontransgenic mice. These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Adelaide, North Tce., Adelaide, South Australia, Australia, 5005. Phone: 61 8 8303 4155. Fax: 61 8 8303 4362. E-mail: ldent{at}microb.adelaide.edu.au.

Infection and Immunity, February 1999, p. 989-993, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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