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Infection and Immunity, March 1999, p. 1505-1507, Vol. 67, No. 3
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Lipopolysaccharide (LPS) from Burkholderia cepacia Is More Active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in Stimulating Tumor Necrosis Factor Alpha from Human Monocytes

Susu M. Zughaier, Henry C. Ryley, and Simon K. Jackson*

Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, United Kingdom

Received 15 June 1998/Returned for modification 26 August 1998/Accepted 19 November 1998

Whole cells and lipopolysaccharides (LPSs) extracted from Burkholderia cepacia, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Escherichia coli were compared in their ability to stimulate tumor necrosis factor alpha (TNF-alpha ) from the human monocyte cell line MonoMac-6. B. cepacia LPS, on a weight-for-weight basis, was found to have TNF-alpha -inducing activity similar to that of LPS from E. coli, which was approximately four- and eightfold greater than the activity of LPSs from P. aeruginosa and S. maltophilia, respectively. The LPS-stimulated TNF-alpha production from monocytes was found to be CD14 dependent. These results suggest that B. cepacia LPS might play a role in the pathogenesis of inflammatory lung disease in cystic fibrosis, and in some patients it might be responsible, at least in part, for the sepsis-like cepacia syndrome.

* Corresponding author. Mailing address: Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, United Kingdom. Phone: 44 1222 744725. Fax: 44 1222 742161. E-mail: JacksonSK{at}CF.AC.UK.

Infection and Immunity, March 1999, p. 1505-1507, Vol. 67, No. 3
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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