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Infection and Immunity, March 1999, p. 1517-1520, Vol. 67, No. 3
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of Moraxella (Branhamella) catarrhalis lbpB, lbpA, and Lactoferrin Receptor orf3 Isogenic Mutants

Robert A. Bonnah,1 Henry Wong,1 Sheena M. Loosmore,2 and Anthony B. Schryvers1,*

Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada T2N 4N1,1 and Pasteur Merieux Connaught Canada Research, Toronto, Ontario, Canada M2R 3T42

Received 14 July 1998/Returned for modification 11 September 1998/Accepted 18 December 1998

Pathogenic members of the family Neisseriaceae produce specific receptors to acquire iron from their host's lactoferrin and transferrin. Recently, putative Moraxella catarrhalis lactoferrin receptor genes and a third open reading frame (lbpB, lbpA, and orf3) were cloned and sequenced. We describe the preliminary characterization of isogenic mutants deficient in LbpB, LbpA, or Orf3 protein.

* Corresponding author. Mailing address: Department of Microbiology and Infectious Diseases, University of Calgary, Heritage Medical Research Building, Health Sciences Center, Calgary, Alberta, Canada T2N 4N1. Phone: (403) 220-3703. Fax: (403) 270-2772. E-mail: schryver{at}ucalgary.ca.

Infection and Immunity, March 1999, p. 1517-1520, Vol. 67, No. 3
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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