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Infection and Immunity, April 1999, p. 2022-2024, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of an Immunogenic Glycocalyx on the Surfaces of Cryptosporidium parvum Oocysts and Sporozoites

Jayasri Nanduri,1,* Selvi Williams,2 Toshiki Aji,3 and Timothy P. Flanigan4

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio1; The Miriam Hospital,4 Brown University School of Medicine,2 Providence, Rhode Island; and Department of Parasitology, Okayama University, Okayama, Japan3

Received 14 May 1998/Returned for modification 24 July 1998/Accepted 14 January 1999

Ruthenium red staining of Cryptosporidium parvum oocysts revealed the presence of a carbohydrate matrix on their outer bilayers that is characteristic of a glycocalyx. Surface labeling of intact oocysts identified material of high molecular weight (>106) that reacted positively with sera from cryptosporidium-infected patients and with immunoglobulin A monoclonal antibodies.

* Corresponding author. Mailing address: Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd., Cleveland, OH 44106. Phone: (216) 368-2590. Fax: (216) 368-5484. E-mail: jxn3{at}po.cwru.edu.

Infection and Immunity, April 1999, p. 2022-2024, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Choudhry, N., Bajaj-Elliott, M., McDonald, V. (2008). The Terminal Sialic Acid of Glycoconjugates on the Surface of Intestinal Epithelial Cells Activates Excystation of Cryptosporidium parvum. Infect. Immun. 76: 3735-3741 [Abstract] [Full Text]  
  • Kuczynska, E., Shelton, D. R., Pachepsky, Y. (2005). Effect of Bovine Manure on Cryptosporidium parvum Oocyst Attachment to Soil. Appl. Environ. Microbiol. 71: 6394-6397 [Abstract] [Full Text]  
  • Butkus, M. A., Bays, J. T., Labare, M. P. (2003). Influence of Surface Characteristics on the Stability of Cryptosporidium parvum Oocysts. Appl. Environ. Microbiol. 69: 3819-3825 [Abstract] [Full Text]  


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