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Infection and Immunity, April 1999, p. 2025-2029, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Clonal Expansion of Antigen-Specific CD4 T Cells following
Infection with Salmonella typhimurium Is Similar in
Susceptible (Itys) and Resistant
(Ityr) BALB/c Mice
Zong-ming
Chen, and
Marc K.
Jenkins*
Department of Microbiology and Center for
Immunology, University of Minnesota Medical School, Minneapolis,
Minnesota 55455
Received 5 August 1998/Returned for modification 22 October
1998/Accepted 25 January 1999
The results show that CD4 T cells specific for a recombinant
antigen expressed in Salmonella typhimurium proliferate
normally in mice that express the susceptible form of the
Ity gene at early times after infection but do not retain
the capacity to produce gamma interferon later in the infection.
*
Corresponding author. Mailing address: University of
Minnesota Medical School, Department of Microbiology and the Center for Immunology, Box 334 UMHC, 420 Delaware St. S.E., Minneapolis, MN
55455. Phone: (612) 626-2715. Fax: (612) 625-2199. E-mail: marcj{at}lenti.med.umn.edu.
Infection and Immunity, April 1999, p. 2025-2029, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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