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 Previous Article

Infection and Immunity, May 1999, p. 2682-2686, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Gamma Interferon and Interleukin-10 Gene Expression in Synovial Tissues from Patients with Early Stages of Chlamydia-Associated Arthritis and Undifferentiated Oligoarthritis and from Healthy Volunteers

Shigeru Kotake,1,dagger H. Ralph Schumacher Jr.,1,2 Thurayya K. Arayssi,1 Herve C. Gérard,3 Patrick J. Branigan,4 Alan P. Hudson,3 Cheryl H. Yarboro,1 John H. Klippel,1 and Ronald L. Wilder1,*

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland1; Department of Veterans Affairs Medical Center2 and Department of Microbiology and Immunology, MCP-Hahnemann School of Medicine,4 Philadelphia, Pennsylvania; and Department of Immunology and Microbiology, Wayne State University Medical School, Detroit, Michigan3

Received 28 July 1998/Returned for modification 28 September 1998/Accepted 12 February 1999

Genetically determined differences in interleukin-10 (IL-10) and gamma interferon (IFN-gamma ) responses in mice correlate with clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IFN-gamma and additional cytokine genes in patients who had recent-onset Chlamydia-associated arthritis (Chl-AA). IL-10 and IFN-gamma mRNA were relatively abundant in recent-onset Chl-AA.

* Corresponding author. Mailing address: ARB, NIAMS, NIH, 10 Center Dr. MSC 1820, Bldg. 10, Rm. 9N228, Bethesda, MD 20892-1820. Phone: (301) 496-6499. Fax: (301) 402-0012. E-mail: wilderr{at}arb.niams.nih.gov.

dagger Present address: Institute of Rheumatology, Tokyo Women's Medical College, Shinjuku-ku, Tokyo 162, Japan.

Infection and Immunity, May 1999, p. 2682-2686, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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