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Infection and Immunity, June 1999, p. 3061-3065, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Transcriptional Activation of mRNA of Intercellular Adhesion Molecule 1 and Induction of Its Cell Surface Expression in Normal Human Gingival Fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans

Li Dong,1 Ken-Ichiro Shibata,1,* Yoshihiko Sawa,2 Akira Hasebe,1 Yuji Yamaoka,3 Shigemitsu Yoshida,2 and Tsuguo Watanabe1

Departments of Oral Bacteriology,1 Oral Anatomy I,2 and Prosthetic Dentistry,3 Hokkaido University School of Dentistry, Kita-Ku, Sapporo 060-8586, Japan

Received 21 December 1998/Returned for modification 15 February 1999/Accepted 26 March 1999

Lipoproteins in the cell membranes of both Mycoplasma salivarium and Mycoplasma fermentans were demonstrated to trigger the transcription of intercellular adhesion molecule-1 mRNA in normal fibroblasts isolated from human gingival tissue and to induce its cell surface expression by a mechanism distinct from that of Escherichia coli lipopolysaccharide. The lipid moiety of the lipoproteins was suggested to play a key role in the expression of the activity.

* Corresponding author. Mailing address: Department of Oral Bacteriology, Hokkaido University School of Dentistry, Nishi 7, Kita 13, Kita-Ku, Sapporo 060-8586, Japan. Phone: 011-706-4241. Fax: 011-706-4901. E-mail: shibaken{at}den.hokudai.ac.jp.

Infection and Immunity, June 1999, p. 3061-3065, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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