This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bermudez, L. E.
Right arrow Articles by Petrofsky, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bermudez, L. E.
Right arrow Articles by Petrofsky, M.

 Previous Article  |  Next Article 

Infection and Immunity, June 1999, p. 3108-3111, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Host Defense against Mycobacterium avium Does Not Have an Absolute Requirement for Major Histocompatibility Complex Class I-Restricted T Cells

Luiz E. Bermudez,* and Mary Petrofsky

Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California 94115

Received 16 November 1998/Returned for modification 4 January 1999/Accepted 29 March 1999

The role of CD8+ T cells was evaluated in a mouse model of disseminated Mycobacterium avium infection. C57BL/6J and C57BL/6Jbeta 2-/- (beta 2-/-) mice were infected intravenously, and the number of viable bacteria in each liver and spleen was determined. No significant difference between the number of bacteria in the two strains of mice was observed at 2, 4, 6, and 8 weeks after infection. Histopathological examination of granulomas from C57BL/6J and beta 2-/- mice did not show any difference either in the number of organisms per granuloma or in the size of the granulomas. Investigation of the cytokine profile in the spleen demonstrated that the beta 2-/- strain of mice produced a significantly lower amount of gamma interferon at 8 weeks after infection and significantly increased concentrations of tumor necrosis factor alpha compared with that from the wild-type mouse. Interleukin-12 and transforming growth factor beta 1 levels did not differ between the two strains of mice at 2, 4, 6, and 8 weeks. Although previous work had found that host response against Mycobacterium tuberculosis involves major histocompatibility complex class I-restricted T cells, our results indicate that chronic deficiency of CD8+ T cells does not lead to a different expression of the disease and that if CD8+ T cells are involved in the host response, their function can be assumed by other immune cells.

* Corresponding author. Mailing address: Kuzell Institute, 2200 Webster St., Suite 305, San Francisco, CA 94115. Phone: (415) 561-1734. Fax: (415) 441-8548. E-mail: luizb{at}cooper.cpmc.org.

Infection and Immunity, June 1999, p. 3108-3111, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Gomes-Pereira, S., Rodrigues, P. N., Appelberg, R., Gomes, M. S. (2008). Increased Susceptibility to Mycobacterium avium in Hemochromatosis Protein HFE-Deficient Mice. Infect. Immun. 76: 4713-4719 [Abstract] [Full Text]  
  • Gilbertson, B., Germano, S., Steele, P., Turner, S., de St. Groth, B. F., Cheers, C. (2004). Bystander Activation of CD8+ T Lymphocytes during Experimental Mycobacterial Infection. Infect. Immun. 72: 6884-6891 [Abstract] [Full Text]  
  • Gilbertson, B., Cheers, C. (2002). Generalized Immunological Decline during Long-Term Experimental Infection with Mycobacterium avium. Infect. Immun. 70: 7145-7148 [Abstract] [Full Text]  
  • Mansfield, K. G., Veazey, R. S., Hancock, A., Carville, A., Elliott, M., Lin, K.-C., Lackner, A. A. (2001). Induction of Disseminated Mycobacterium avium in Simian AIDS Is Dependent upon Simian Immunodeficiency Virus Strain and Defective Granuloma Formation. Am. J. Pathol. 159: 693-702 [Abstract] [Full Text]  
  • Nagabhushanam, V., Cheers, C. (2001). Non-Major Histocompatibility Complex Control of Antibody Isotype and Th1 versus Th2 Cytokines during Experimental Infection of Mice with Mycobacterium avium. Infect. Immun. 69: 1708-1713 [Abstract] [Full Text]  
  • Mohagheghpour, N., van Vollenhoven, A., Goodman, J., Bermudez, L. E. (2000). Interaction of Mycobacterium avium with Human Monocyte-Derived Dendritic Cells. Infect. Immun. 68: 5824-5829 [Abstract] [Full Text]  
  • Ehlers, S., Kutsch, S., Ehlers, E. M., Benini, J., Pfeffer, K. (2000). Lethal Granuloma Disintegration in Mycobacteria-Infected TNFRp55-/- Mice Is Dependent on T Cells and IL-12. J. Immunol. 165: 483-492 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»