This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Magez, S.
Right arrow Articles by De Baetselier, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Magez, S.
Right arrow Articles by De Baetselier, P.

 Previous Article  |  Next Article 

Infection and Immunity, June 1999, p. 3128-3132, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Tumor Necrosis Factor Alpha Is a Key Mediator in the Regulation of Experimental Trypanosoma brucei Infections

Stefan Magez,1,* Magdalena Radwanska,2 Alain Beschin,1 Kenji Sekikawa,3 and Patrick De Baetselier1

Laboratory of Cellular Immunology, Flanders Interuniversity Institute for Biotechnology, Free University of Brussels (Vrije Universiteit Brussel),1 and Department of Molecular Parasitology, Free University on Brussels (Université Libre de Bruxelles),2 Brussels, Belgium, and Division of Host Defense Research, National Institute of Animal Health, Tsukuba City, Japan3

Received 2 July 1998/Returned for modification 23 September 1998/Accepted 2 March 1999

In order to evaluate during experimental Trypanosoma brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha ) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha -/-) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites. In the TNF-alpha -/- mice, the peak levels of parasitemia were strongly increased compared to the peak levels recorded in wild-type mice. The increased parasite burden did not reflect differences in clearance efficacy or in production of T. brucei-specific immunoglobulin M (IgM) and IgG antibodies. Trypanosome-mediated immunopathological features, such as lymph node-associated immunosuppression and lipopolysaccharide hypersensitivity, were found to be greatly reduced in infected TNF-alpha -/- mice. These results demonstrate that, during trypanosome infections, TNF-alpha is a key mediator involved in both parasitemia control and infection-associated pathology.

* Corresponding author. Mailing address: Eenheid CIMM (IMOL2), Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Paardenstraat 65, 1640 Sint Genesius Rode, Belgium. Phone: 32-2-3590301. Fax: 32-2-3590359. E-mail: stemagez{at}vub.ac.be.

Infection and Immunity, June 1999, p. 3128-3132, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Forlenza, M., Magez, S., Scharsack, J. P., Westphal, A., Savelkoul, H. F. J., Wiegertjes, G. F. (2009). Receptor-Mediated and Lectin-Like Activities of Carp (Cyprinus carpio) TNF-{alpha}. J. Immunol. 183: 5319-5332 [Abstract] [Full Text]  
  • Ramey, K., Eko, F. O., Thompson, W. E., Armah, H., Igietseme, J. U., Stiles, J. K. (2009). Immunolocalization and Challenge Studies Using a Recombinant Vibrio cholerae Ghost Expressing Trypanosoma brucei Ca2+ ATPase (TBCA2) Antigen. Am J Trop Med Hyg 81: 407-415 [Abstract] [Full Text]  
  • Dagenais, T. R., Freeman, B. E., Demick, K. P., Paulnock, D. M., Mansfield, J. M. (2009). Processing and Presentation of Variant Surface Glycoprotein Molecules to T Cells in African Trypanosomiasis. J. Immunol. 183: 3344-3355 [Abstract] [Full Text]  
  • Guilliams, M., Movahedi, K., Bosschaerts, T., VandenDriessche, T., Chuah, M. K., Herin, M., Acosta-Sanchez, A., Ma, L., Moser, M., Van Ginderachter, J. A., Brys, L., De Baetselier, P., Beschin, A. (2009). IL-10 Dampens TNF/Inducible Nitric Oxide Synthase-Producing Dendritic Cell-Mediated Pathogenicity during Parasitic Infection. J. Immunol. 182: 1107-1118 [Abstract] [Full Text]  
  • Lopez, R., Demick, K. P., Mansfield, J. M., Paulnock, D. M. (2008). Type I IFNs Play a Role in Early Resistance, but Subsequent Susceptibility, to the African Trypanosomes. J. Immunol. 181: 4908-4917 [Abstract] [Full Text]  
  • Bosschaerts, T., Guilliams, M., Noel, W., Herin, M., Burk, R. F., Hill, K. E., Brys, L., Raes, G., Ghassabeh, G. H., De Baetselier, P., Beschin, A. (2008). Alternatively Activated Myeloid Cells Limit Pathogenicity Associated with African Trypanosomiasis through the IL-10 Inducible Gene Selenoprotein P. J. Immunol. 180: 6168-6175 [Abstract] [Full Text]  
  • Stijlemans, B., Baral, T. N., Guilliams, M., Brys, L., Korf, J., Drennan, M., Van Den Abbeele, J., De Baetselier, P., Magez, S. (2007). A Glycosylphosphatidylinositol-Based Treatment Alleviates Trypanosomiasis-Associated Immunopathology. J. Immunol. 179: 4003-4014 [Abstract] [Full Text]  
  • Harris, T. H., Mansfield, J. M., Paulnock, D. M. (2007). CpG Oligodeoxynucleotide Treatment Enhances Innate Resistance and Acquired Immunity to African Trypanosomes. Infect. Immun. 75: 2366-2373 [Abstract] [Full Text]  
  • Namangala, B., Sugimoto, C., Inoue, N. (2007). Effects of Exogenous Transforming Growth Factor {beta} on Trypanosoma congolense Infection in Mice. Infect. Immun. 75: 1878-1885 [Abstract] [Full Text]  
  • Caljon, G., Van Den Abbeele, J., Stijlemans, B., Coosemans, M., De Baetselier, P., Magez, S. (2006). Tsetse Fly Saliva Accelerates the Onset of Trypanosoma brucei Infection in a Mouse Model Associated with a Reduced Host Inflammatory Response. Infect. Immun. 74: 6324-6330 [Abstract] [Full Text]  
  • Harris, T. H., Cooney, N. M., Mansfield, J. M., Paulnock, D. M. (2006). Signal transduction, gene transcription, and cytokine production triggered in macrophages by exposure to trypanosome DNA.. Infect. Immun. 74: 4530-4537 [Abstract] [Full Text]  
  • Drennan, M. B., Stijlemans, B., Van Den Abbeele, J., Quesniaux, V. J., Barkhuizen, M., Brombacher, F., De Baetselier, P., Ryffel, B., Magez, S. (2005). The Induction of a Type 1 Immune Response following a Trypanosoma brucei Infection Is MyD88 Dependent. J. Immunol. 175: 2501-2509 [Abstract] [Full Text]  
  • MacLean, L., Chisi, J. E., Odiit, M., Gibson, W. C., Ferris, V., Picozzi, K., Sternberg, J. M. (2004). Severity of Human African Trypanosomiasis in East Africa Is Associated with Geographic Location, Parasite Genotype, and Host Inflammatory Cytokine Response Profile. Infect. Immun. 72: 7040-7044 [Abstract] [Full Text]  
  • Kitani, H., Black, S. J., Nakamura, Y., Naessens, J., Murphy, N. B., Yokomizo, Y., Gibson, J., Iraqi, F. (2002). Recombinant Tumor Necrosis Factor Alpha Does Not Inhibit the Growth of African Trypanosomes in Axenic Cultures. Infect. Immun. 70: 2210-2214 [Abstract] [Full Text]  
  • Magez, S., Stijlemans, B., Caljon, G., Eugster, H.-P., De Baetselier, P. (2002). Control of Experimental Trypanosoma brucei Infections Occurs Independently of Lymphotoxin-{alpha} Induction. Infect. Immun. 70: 1342-1351 [Abstract] [Full Text]  
  • Shoda, L. K. M., Kegerreis, K. A., Suarez, C. E., Roditi, I., Corral, R. S., Bertot, G. M., Norimine, J., Brown, W. C. (2001). DNA from Protozoan Parasites Babesia bovis, Trypanosoma cruzi, and T. brucei Is Mitogenic for B Lymphocytes and Stimulates Macrophage Expression of Interleukin-12, Tumor Necrosis Factor Alpha, and Nitric Oxide. Infect. Immun. 69: 2162-2171 [Abstract] [Full Text]  
  • Namangala, B., De Baetselier, P., Noël, W., Brys, L., Beschin, A. (2001). Alternative versus classical macrophage activation during experimental African trypanosomosis. J. Leukoc. Biol. 69: 387-396 [Abstract] [Full Text]  
  • Magez, S., Radwanska, M., Stijlemans, B., Van Xong, H., Pays, E., De Baetselier, P. (2001). A Conserved Flagellar Pocket Exposed High Mannose Moiety Is Used by African Trypanosomes as a Host Cytokine Binding Molecule. J. Biol. Chem. 276: 33458-33464 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»