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Infection and Immunity, June 1999, p. 3166-3167, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunity in Experimental Murine Filariasis: Roles of T and B Cells Revisited

Subash Babu,1 Leonard D. Shultz,2 Thomas R. Klei,3 and T. V. Rajan1,*

University of Connecticut Health Center, Farmington, Connecticut1; The Jackson Laboratory, Bar Harbor, Maine2; and Louisiana State University, Baton Rouge, Louisiana3

Received 13 January 1999/Returned for modification 22 February 1999/Accepted 30 March 1999

We have reevaluated the contributions of T and B cells in Brugia malayi infection by utilizing knockout mice on a uniform background (C57BL/6J). We find that B-cell-deficient mice are more permissive to infection than T-cell-deficient mice.

* Corresponding author. Mailing address: Department of Pathology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030-3105. Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail: rajan{at}neuron.uchc.edu.

Infection and Immunity, June 1999, p. 3166-3167, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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