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Infection and Immunity, June 1999, p. 3171-3174, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Proinflammatory Activation of Neutrophils and Monocytes by Helicobacter pylori in Patients with Different Clinical Presentations

Per Syrak Hansen,1,* Mae F. Go,2 Kim Varming,1 Leif P. Andersen,3 Robert M. Genta,4 David Y. Graham,2 and Henrik Nielsen5

Department of Clinical Immunology1 and Division of Infectious Diseases,5 Aalborg Hospital, Aalborg, and Department of Clinical Microbiology, National University Hospital (Rigshospitalet), Copenhagen,3 Denmark, and Department of Medicine2 and Department of Pathology,4 Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas

Received 28 January 1999/Returned for modification 2 March 1999/Accepted 2 April 1999

Chronic Helicobacter pylori infection is associated with mucosal inflammation. The aim of the present study was to assess human neutrophil and monocyte activation by H. pylori strains obtained from patients with different clinical presentations. Bacterial sonicates from 12 strains were used to stimulate phagocyte upregulation of CD11b/CD18 adherence molecules assessed by fluorescence flow cytometry and oxidative burst responses assessed by chemiluminescence. A dose-dependent activation of CD11b/CD18 adherence molecules was observed with all strains on both neutrophils and monocytes. The activities were similar for strains from patients with duodenal ulceration and for strains from asymptomatic volunteers irrespective of histopathologic grades of the biopsy specimens from the antral mucosa. The neutrophil chemiluminescence response correlated with histopathologic severity. We conclude that upregulation of neutrophil and monocyte adherence molecules by H. pylori sonicates is not associated with clinical presentation of the infection.

* Corresponding author. Mailing address: Department of Clinical Immunology, Aalborg Hospital, DK-9100 Aalborg, Denmark. Phone: 45 9932 1150. Fax: 45 9932 1139. E-mail: syrak{at}aas.nja.dk.

Infection and Immunity, June 1999, p. 3171-3174, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Teneberg, S., Jurstrand, M., Karlsson, K.-A., Danielsson, D. (2000). Inhibition of nonopsonic Helicobacter pylori-induced activation of human neutrophils by sialylated oligosaccharides. Glycobiology 10: 1171-1181 [Abstract] [Full Text]  


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